Clinical Endocannibinoid Deficiency Syndrome

What is Clinical Endocannibinoid Deficiency Syndrome?  To start, a syndrome is a concurrence of symptoms that happen on a regular basis.  In other words, they always happen and happen together.  What is the Endocannibinoid System?  A system in mammals that emerged with the discovery of cannibinoid receptors in the brain in 1988 and then with the discovery of the first naturally occurring cannibinoid, Anandamide, in 1992.  In terms of scientific study, this system is very new and the study of it is ongoing. Most people have not yet heard of the Endocannibinoid System and may wonder if this syndrome is something fabricated by the hemp growers society or some other imaginary group that sits around trying to figure out how to make a profit off hemp sales beyond the usual known uses.  I promise you this is a real medically researched syndrome that researchers all over the world are trying to understand.  One of the most well know scientists on the job is Dr. Ethan Russo. He has been studying the endocannibinoid system for many years and, I believe, is one of the best authorities on the subject. He has published many scientific papers and several books.  Here is some of what I have learned on subject close to my heart.

The Endocannibinoid System consists of endogenous lipid based neurotransmitters that bind to endocannibinoid receptors in the body. CB1 receptors are primarily associated with brain function. CB2 with the digestive system and immune function and major organs. The Endocannibinoid System regulates homeostasis in the body, making sure there’s balance within. Any dysfunction or damage to this system may affect eating, sleeping, pain, inflammation and the overall harmony of your system. Scientists believe there is an endocannibinoid tone. Each person has an individual amount of Endocannibinoid receptors and each body produces a certain amount of endocannibinoids, resulting in a unique picture called  endocannibinoid tone. if something happens to disrupt that tone there will be damage to the equilibrium of the body. This can manifest in a number of ways.  One area being studied is the lowering of the pain threshold in the body. Dr. Russo believes that the evidence of this is found in migraines, fibromyalgia, and irritable bowel syndrome; all very similar and overlapping syndromes where there is pain but no viable reason for it. There is pain without tissue damage or injury. So if your body can’t make the Endocannibinoids it needs what can you do? There is quite a bit of research proving that phytocannabinoids from plants, primarily the hemp or cannabis plant, can act on the endocannibinoid receptors in our body.  The Fido cannibinoid we’re talking about is CBD. It’s an excellent anti-inflammatory, anti-anxiety anti-psychotic, and anti-convulsant. Incredible success has been achieved in controlling seizures.  CBD is an Endo modulator. When taken on a regular basis it actually increases the gain of the endocannibinoid system. This system regulates neurotransmitter function which many diseases affect.  Deficiency in the function of the endocannibinoid system would lead to pain, nausea, a lower seizure threshold and many other problems. Dr. Russo’s belief that these syndromes are tied to the Endocannibinoid system was supported by a recent study in Italy that measured the spinal fluid of migraine patients and found that they were deficient in anandimide compared to people who did not suffer from migraines. Anandimide is an Endocannibinoid. Some things that could influence the function of this system are poor eating habits and lack of exercise.These may add to the imbalance and have a bearing on the dysfunction or damage to the Endocannibinoid system. Other compounds of cannabis have also been found to be cannabinoids and work together with CBD to positively affect the Endocannibinoid system. These compounds working together are known as the full entourage affect .This entourage effect assists the endocannibinoid system to function smoothly, in turn creating harmony. This explains Dr. Russo’s belief that the longer you take cannibinoids you boost the system and get more gain. Both of my sources, consisting of Dr. Russo’s published work on endocannibinoid deficiency and his interview with Project CBD, took place in 2016 it’s 2019 now with the passing of several years we can reasonably expect more knowledge has been gained through research and will be available to the public in the near future for now the key phrase that I pulled from my research on the Endo can system and Endo can deficiency was the fact that cannabinoids modulate the Endo can system and over time increase the gain to me this means if you keep working with your and a cannabinoids system by taking CBD on a regular basis it may take time but you will see improvement.  I’ve had fibromyalgia for more than 30 years. The research on CECD gives me hope that someday I’ll live a painfree life.  Prior to CBD and the discovery of Clinical Endocannibinoid Syndrome, I didn’t have any hope.

As I mentioned earlier, many scientists all over the world have joined in the research of the Endocannibinoid System and what dysfunction of this system could do to the body, but Dr. Russo speaks in terms that the average person can understand.  The link to a very good interview Project CBD held with Dr. Russo on Clinical Endocannibinoid Syndrome is below.  Clinical Endocannibinoid Syndrome is real and many have found relief from CBD regardless of the way CES manifests in their system.
Ethan B. Russo.Cannabis and Cannabinoid Research.Dec 2016.ahead of print http://doi.org/10.1089/can.2016.0009

https://www.projectcbd.org/science/cannabis-pharmacology/dr-ethan-russo-cbd-clinical-endocannabinoid-deficiency